Because EWS-FLI1 low cells express more basal ICAM-1 and tumor ICAM-1 can enhance tumor cell: T-cell interaction and T-cell activation [19, 20], we hypothesized that EWS-FLI1 low cells would be more susceptible to T-cell mediated tumor cell killing as compared to tumor cells with higher EWS-FLI1 expression. The gene discussed is ICAM1; the disease is neoplasm.