A more dramatic loss of function is identified in the TRMT11-GRIK2 gene fusion; the TRMT11-GRIK2 gene fusion eliminates the open-reading frame of GRIK2, which is a potential tumor suppressor [30, 31], and produces a large truncation of TRMT11, which is a tRNA methyltransferase [32, 33]. Here, TRMT11 is linked to neoplasm.