In contrast, the observation that either pre- or post-application of NF-κB inhibitor results in profound inhibition of acidic bile-induced “downregulation” of “tumor suppressor” miR-451a, emphasizes that even late inhibition of NF-κB is capable of suppressing acidic bile-deregulation of a “tumor suppressor’ miRNA marker, we previously identified as related to laryngopharyngeal carcinogenesis [37]. Here, NFKB1 is linked to neoplasm.