Our novel data from miRNA analysis show that either pre- or post-application of BAY 11-7082 can effectively prevent the acidic bile-induced deregulation of specific cancer-related miRNA markers, further supporting the observation that acidic bile-induced NF-κB activation may directly or indirectly regulate the expression of small regulatory molecules, miR-21, miR-155, miR-192, miR-375 and miR-451a [7, 9, 10]. Here, NFKB1 is linked to cancer.