LRP1B and melanoma: Melanoma samples with LRP1B mutations had a significantly higher tumor mutation burden and neoantigen burden by Wilcoxon rank sum test (log2 TMB, 9.5 vs. 7.3, P < 0.001; log2 NB, 9.2 vs. 6.9, P < 0.001; Figures 3A,B).