NRAS and melanoma: The well-known melanoma driver oncogenes (e.g., BRAF, NRAS, NF1, PREX2, ARID2, PPP6C, CCBE1, PTEN), genomic integrity maintenance and DNA replication proofreading associated genes (e.g., TP53, ATR, BRCA1/2, MRE11A) and common LRPs (i.e., LRP1, LRP2, LRP3, LRP4, LRP5, LRP6, LRP8, LRP10, and LRP12) in relation to LRP1B mutation were illustrated in waterfall plot (Figure 1B).