The well-known melanoma driver oncogenes (e.g., BRAF, NRAS, NF1, PREX2, ARID2, PPP6C, CCBE1, PTEN), genomic integrity maintenance and DNA replication proofreading associated genes (e.g., TP53, ATR, BRCA1/2, MRE11A) and common LRPs (i.e., LRP1, LRP2, LRP3, LRP4, LRP5, LRP6, LRP8, LRP10, and LRP12) in relation to LRP1B mutation were illustrated in waterfall plot (Figure 1B). The gene discussed is PREX2; the disease is melanoma.