First, we probed our previously reported SLE-associated region (chr15: 38.4–39.2 MB, hg19) and extracted association results for six cohorts from the region containing the genes RASGRP1 (RAS guanyl-releasing protein 1, a diacylglycerol-regulated guanine nucleotide exchange factor) and C15orf53 [encoding a protein of unknown function linked to alcohol dependence (55)]. This evidence concerns the gene RASGRP1 and alcohol dependence.