To identify putative functional SLE SNPs in and around RASGRP1, we computed weighted scores for each SNP by integrating multiple sources of functional annotation, including allele-dependent gene expression, overlap with annotated enhancers and promoters, binding affinity to transcription factors, and collocation with anchors in promoter-enhancer-capture Hi-C experiments (Supplementary Table 2). Here, RASGRP1 is linked to systemic lupus erythematosus.