Interestingly in another report, C4F6 was shown to react only with SOD1 mutants in ALS affected tissues and cells, whereas the tissues and cells not affected by the disease containing high levels of mutant proteins were not recognized by C4F6 (63), indicating that in ALS affected tissues or cells, the SOD1 mutant can adopt the forms recognized by C4F6. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.