Thus, it is conceivable that in SOD1 mutant-caused ALS, the overall decline of autophagic flux may be induced by the association of SOD1 mutants with p62/SQSTM1, although the association of the two can promote autophagy to remove misfolded SOD1 mutants to some extent in the early disease stages. Here, SOD1 is linked to amyotrophic lateral sclerosis.