Furthermore, the drug NC-6300 is thought to potentially cause retinal hemorrhages (Mukai et al., 2017), and EPI hydrochloride, the active substance of NC-6300, is considered to cause serious adverse events such as myocardial disorder, myelosuppression, and anaphylaxis, as well as other adverse events such as cardiac dysrhythmia, hives, abnormal hepatic function (increase in aspartate transaminase [glutamic oxaloacetic transaminase], alanine transaminase [glutamic pyruvic transaminase], etc.), abnormal kidney function (increase in blood urea nitrogen, etc.), and asitia (FDA, 2018). This evidence concerns the gene GPT and cardiac arrhythmia.