PARP1 and pulmonary fibrosis: Moreover, recent studies demonstrated that genetic depletion and pharmacological inhibition of PARP-1 reduced pulmonary fibrosis in an animal model of bleomycin-induced lung injury (Hu et al., 2013; Lucarini et al., 2017), suggesting that PARylation is important for myofibroblast differentiation and for the pathogenesis of the disease.