More specifically, studies have also shown downregulation of Nrf2 in depression and that Nrf2 activators, such as sulforaphane and its precursor glucoraphanin, exert antidepressive-like effects in depression (Martín-de-Saavedra et al., 2013; Yao et al., 2016). Here, NFE2L2 is linked to major depressive disorder.