NFE2L2 and Huntington disease: Although Nrf2 is predominantly expressed in astrocytes, overactivation of Nrf2 in astrocytes is protective in various neurogenerative diseases such as Parkinson’s disease (Chen et al., 2009), amyotrophic lateral sclerosis (Vargas et al., 2008), Huntington’s disease (Shih et al., 2005), and multiple sclerosis (Draheim et al., 2016).