In addition, immunohistochemical analysis of glial fibrillary acidic protein, an astrocytic marker, revealed a significantly reduced area covered by glial fibrillary acidic protein-positive cell bodies and processes in various brain regions of young patients with depression compared to a control group (Müller et al., 2001; Fatemi et al., 2004; Miguel-Hidalgo et al., 2010; Gittins and Harrison, 2011; Chandley et al., 2013). Here, GFAP is linked to major depressive disorder.