Xiao and Zhang’s study has demonstrated that TFEB can regulate production of autophagosomes and degradation of lysosomes by the autophagy-lysosomal pathway in the mouse model of AD, which accelerates Aβ and amyloid plaques clearance (Xiao et al., 2014, 2015; Zhang and Zhao, 2015) and improves the cognitive function of mouse (Zhang and Zhao, 2015). This evidence concerns the gene TFEB and Alzheimer disease.