SYN1 and epilepsy: In this scenario, SynI deficiency, which has been associated with I/E imbalances and identified as an epilepsy and autism predisposing gene in humans (Garcia et al., 2004; Fassio et al., 2011; Lignani et al., 2013; Nguyen et al., 2015; Peron et al., 2018) offers the possibility to explore amygdala-related pathogenic mechanisms under a SynI loss-of-function condition.