FMR1 and amyotrophic lateral sclerosis: FMRP is a known binding partner of TDP-43; in patients with Fragile × syndrome (whereby they have a repeat-expansion in the FMR1 gene and acquire FMRP inclusions), profiling these inclusions demonstrated that many astrocytic proteins have been associated with these FMR inclusions, including vimentin, GFAP, and hnRNP A2/B1 [and, interestingly, myelin basic protein (MBP; Iwahashi et al., 2005)] Given FMRP is a known binding partner of TDP-43, these protein associations are relevant to ALS.