MBP and amyotrophic lateral sclerosis: Of relevance, in human post-mortem tissue, it has been shown that ALS patients have a significant reduction in MBP in both the motor cortex and ventral spinal cord (Kang et al., 2013); however, it remains unclear as to whether the reduced myelin is a downstream effect of axonal loss or whether it is an intrinsic deficit in oligodendrocytes.