Another key astrocytic mRNA known to be locally translated is excitatory amino acid transporter-2 (EAAT2) and whilst its trafficking has not been explored, EAAT2 transcripts with both intron-retention and exon-skipping have been found in 65% of sporadic ALS patients in neuropathologically affected areas as well as in the cerebrospinal fluid (CSF; Lin et al., 1998). This evidence concerns the gene SLC1A2 and amyotrophic lateral sclerosis.