TARDBP and amyotrophic lateral sclerosis: TDP-43 is a binding partner for EAAT2, the glutamate transporter introduced above, and it has been shown that TDP-43 aggregation correlates with decreased EAAT1/2 glutamate transporter levels in the spinal cords of both an ALS mouse model (Tong et al., 2013) and human patients (Rothstein et al., 1995).