More specifically, it has been shown that co-culturing induced pluripotent stem cell (iPSC)-derived oligodendrocytes from sporadic ALS patients, as well as those harboring mutations in C9orf72 and TDP-43, with HB9-GFP motor neurons led to significant motor neuron loss compared to co-cultures with iPSC-derived oligodendrocytes from healthy control patients (Ferraiuolo et al., 2016). Here, TARDBP is linked to amyotrophic lateral sclerosis.