MECP2 and glioblastoma: Coady and Manley (2015) used the human glioblastoma cell line, U87, to show that mutations in FUS can lead to reduced MeCP2 levels (a transcription factor regulator); reduced MeCP2 protein levels in glia has previously been shown to be toxic to neurons leading to altered dendritic morphology and, ultimately, neuronal death (Ballas et al., 2009).