Moreover, we propose that effects of PROM1 and PROM2 on cancer progression and prognosis, may be more prominent when associated with their respective co-expressed genes, such as ANXA3 and TACSTD2 for PROM1 and LAD1 and C1ORF106 for PROM2. Furthermore, in this study, we demonstrated that PROM1 and PROM2 perform different functions with respect to pathway regulation. Here, ANXA3 is linked to cancer.