The 506 genes to which multiple male SALS twin probes annotate are given in Supplementary Table S7, which includes two genes previously associated with ALS, DPP6 (Dipeptidyl Peptidase Like 6) and RAMP3 (Receptor Activity Modifying Protein 3) (Fig. 5A). This evidence concerns the gene DPP6 and amyotrophic lateral sclerosis.