Interestingly, the tongue SCC ITOC-02 cell line had truncating mutations in a few genes which are rarely associated with some cancers, PYROXD2, PCMTD1 reported to be mutated in hepatocellular cancer36,37 and PABCP1 reported to be upregulated in gastric carcinoma and targeting miR-34c38. The gene discussed is PYROXD2; the disease is cancer.