Furthermore, we searched the publicly available Oncomine database (https://www.oncomine.org) and TCGA (The Cancer Genome Atlas) database analytical website: UALCAN (http://ualcan.path.uab.edu/index.html)49 about the transcriptome data of NUDT1(MTH1) in stomach adenocarcinoma (STAD) (Supplementary Fig. 2A, B), esophageal carcinoma (ESCA) (Supplementary Fig. 2D) and liver hepatocellular carcinoma (LIHC) (Supplementary Fig. 2E). This evidence concerns the gene NUDT1 and cancer.