Furthermore, we searched the publicly available Oncomine database (https://www.oncomine.org) and TCGA (The Cancer Genome Atlas) database analytical website: UALCAN (http://ualcan.path.uab.edu/index.html)49 about the transcriptome data of NUDT1(MTH1) in stomach adenocarcinoma (STAD) (Supplementary Fig. 2A, B), esophageal carcinoma (ESCA) (Supplementary Fig. 2D) and liver hepatocellular carcinoma (LIHC) (Supplementary Fig. 2E). The gene discussed is NUDT1; the disease is carcinoma of esophagus.