In 2014, two MTH1 inhibitors(TH588 and (S)-crizotinib) were firstly reported10,23 and recognized as novel small-molecule inhibitors to effectively target this protein and exhibit good anti-proliferation effects in various cancer cells(U2OS, Hela, MCF7, MDA-MB-231, SW480, SW620, DU145 and A549). Here, NUDT1 is linked to cancer.