NUDT1 and signet ring cell gastric adenocarcinoma: Moreover, we found that in GC subtypes: Gastric Tubular Adenocarcinoma, Gastric Adenocarcinoma, Gastric Intestinal Type Adenocarcinoma, Diffuse Gastric Adenocarcinoma, Mucinous Gastric Adenocarcinoma, Signet Ring Cell Gastric Adenocarcinoma and Gastric Papillary Adenocarcinoma, MTH1 was also obviously overexpressed, compared with non-tumor gastric tissues, but there is no big difference among them (Supplementary Fig. 3A).