XRN1 and Familial prostate cancer: Our previous study in prostate cancer was the first to demonstrate that IFIT5 could recognize and bind to certain specific pre-miRNA that had an overhang at its 5′ end, and then recruited the exoribonuclease XRN1 to degrade IFIT5-bound miRs such as miR-363, miR-101, and miR-128 with suppressive function4.