To further detect the role of STYK1 on NSCLC cell lines from the primary sites, we then overexpressed the STYK1 in SK-LU-1 cells and found STYK1 overexpression also enhanced the migratory and invasive abilities in SK-LU-1 cells (supplementary Fig. S2A). Here, STYK1 is linked to non-small cell lung carcinoma.