Interestingly, in the NSCLC group and the LUAD subgroup, there was no statistically difference of patients’ survival between the low STYK1/low SPINT2 group with high STYK1/high SPINT2 group (P > 0.05, Fig. 6e, f); whereas LUSC with high STYK1/high SPINT2 showed better prognosis than LUSC with low STYK1/low SPINT2 (P = 0.007, Fig. 6g). The gene discussed is STYK1; the disease is non-small cell lung carcinoma.