To confirm the results observed in ANGPTL4 knockout mice and to explore the therapeutic potential of anti-cANGPTL4 treatment, we next studied the effects of an cANGPTL4 deficiency caused by the injection of an anti-cANGPTL4 monoclonal antibody (MAb) into secondary pneumococcal pneumonia-infected mice. This evidence concerns the gene ANGPTL4 and pneumococcal pneumonia.