References were identified through searches of PubMed for articles published from 2000, by the use of the terms ‘selective peroxisome proliferator-activated receptor alpha’; ‘nuclear receptor’; ‘fibrate’; ‘remnant cholesterol’; ‘cardiovascular risk’; ‘residual risk’; ‘triglyceride-rich lipoproteins’; ‘non-alcoholic fatty liver disease’; ‘pemafibrate (K-877)’; in combination with the term’ diabetes‘, ‘obesity’, ‘atherosclerotic cardiovascular disease’ and ‘non-alcoholic fatty liver disease’. This evidence concerns the gene PPARA and metabolic dysfunction-associated steatotic liver disease.