Loss-of-function (LOF) variants in genes encoding apo AV and LpL associate with lifelong higher plasma TG levels and an increased risk of coronary artery disease [75–78], whereas LOF mutations in APOC3 and ANGPTL4 associate with lifelong decreased plasma TG levels and reduction in the risk of coronary artery disease [79–82]. Here, APOA5 is linked to coronary artery disorder.