Involvement of several molecules of the PI3K–Akt pathways in GC carcinogenesis has eventually led to development of both single, as well as recently, dual inhibitors essential for molecular targeted therapy for GC, including pan-class I inhibitors, isoform specific PI3K inhibitors, Akt inhibitors, dual Akt/mTOR inhibitors [34]. Here, AKT1 is linked to gastric cancer.