ERBB2 and neoplasm: Moreover, these findings have been further validated in three HER2-amplified mCRC patient derived xenografts, which could better resemble the complexity of a human mCRC, since these models have been demonstrated as a better surrogate of human cancer and may represent a valid experimental tool to overcome the limitations of in vitro models by faithfully recapitulating the histological and functional heterogeneity observed in primary tumor samples.