Furthermore, in HER2-amplified LIM1215-HER2 and SW48-HER2 colon cancer cells HER2 activation was accompanied by the interaction of HER2 with both EGFR and HER3, respectively, by forming HER2/EGFR and HER2/HER3 complexes. This evidence concerns the gene ERBB3 and malignant colon neoplasm.