Multivariate analysis revealed that γ-glutamyl transferase (GGT) (hazard ratio (HR), 1.002; 95% CI, 1.000–1.004; P = 0.01), tumor diameter (HR, 1.100; 95% CI, 1.046–1.156; P < 0.001), tumor differentiation (Edmondson-Steiner grade I-II/III-IV) (HR, 1.819; 95% CI, 1.268–2.610; P = 0.001) [41], and TRIS (HR, 4.606; 95% CI, 1.335–15.890; P = 0.02) were independent prognostic factors of OS in HCC patients. This evidence concerns the gene PRDM10 and hepatocellular carcinoma.