F2 and hepatocellular carcinoma: Third, our study only analyzed the impact of some parameters on the OS and DFS in HCC patients, while other parameters such as prothrombin induced by vitamin K absence-II (PIVKA-II) [31], carcinoembryonic antigen (CEA) [32], the Barcelona Clinic Liver Cancer (BCLC) staging system [33], were not taken into account in this study.