TRAP1 and neoplasm: In wild-type IDH1/2 tumors, under hypoxia or pseudohypoxia, like in a TRAP1 upregulated tumor environment [50], the production of the oncometabolite L-2-HG is frequent via the “promiscuous” reduction of α-KG, catalyzed by lactate dehydrogenase (LDHA) jointly with malate dehydrogenase (MDH) [141].