In summary, the results indicated that phenolics and phyto-antioxidant constituents of the herbal mixture including zingiberene, α-curcumene, β-sesquiphellandrene, α-farnesene, β-bisabolene, cinnamic aldehyde, and pulegone could effectively improve antioxidant potential, and the levels of FBS, HOMA-IR, and insulin in the serum of PCOS patients. The gene discussed is INS; the disease is polycystic ovary syndrome.