Therefore, the aims of this study were to compare the efficacy of four herbal mixtures with CC on serum antioxidants (CAT, GPX, SOD, MDA) and glycemic biomarkers (insulin, insulin resistance, and FBS) as primary outcomes in PCOS patients, and to determine total phenolic content (TPC), total flavonoid content (TFC), free radical scavenging activity, ferric reducing antioxidant potential (FRAP), and phytochemical analysis of herbal mixture as secondary outcome. This evidence concerns the gene SOD1 and Insulin resistance.