In AOM/DSS mouse models, knocking down genes that code for DNA damage repair-related enzymes, e.g., Alkyladenine DNA glycosylase (Aag), mutY DNA glycosylase (Mutyh), 8-oxoguanine DNA glycosylase 1 (Ogg1), may increase CRC incidence [9,30,32]. Here, MPG is linked to colorectal carcinoma.