VEGFA and Down syndrome: Phase I clinical studies of 300 doses of haNK cells in combination with a vaccine cocktail composed of, among others, recombinant human super agonist IL-15, nab-paclitaxel, anti-PDL1 monoclonal antibody, and anti-vascular endothelial growth factor (VEGF) monoclonal antibody, resulted in zero incidence of cytokine release syndrome.