In fact, crude drug number 107 (Binroji; areca) has been reported to induce autophagy in several cell lines, such as leukemic Jurkat T cells [39] and oral carcinoma cells (OECM-1), Cal-27, and Scc-9 [40] by activating the AMPK/mTOR signaling pathway after accumulating reactive oxygen species [40]. This evidence concerns the gene MTOR and lip and oral cavity carcinoma.