FLT3 and acute myeloid leukemia: The clinical development of midostaurin is still ongoing, and other studies have been designed, exploring the combination with decitabine in elderly AML patients (NCT01846624, recently closed to the enrollment), or the potential role of the drug in FLT3-negative AML patients (NCT03512197) exploiting its wide spectrum of action, directed to many further molecular targets, besides FLT3.