This was a multicenter, double-blind placebo-controlled study, which enrolled 717 adult patients (18–59 years of age) affected by newly diagnosed FLT3-mutated AML [22], randomized to receive either a standard program of chemotherapy based on induction (daunorubicin + cytarabine) and consolidation (high-dose cytarabine) plus a placebo (n = 357) or midostaurin (n = 360), at a dosage of 50 mg twice daily on days 8 through 21; after the end of consolidation therapy, patients who were still in remission went on to receive midostaurin or a placebo for 12 months. The gene discussed is FLT3; the disease is acute myeloid leukemia.