Additionally, MMP-7 can act as a sheddase for syndecan-1 [235,236], a major transmembrane heparan sulfate proteoglycan expressed on the surface (glycocalyx) of epithelial, endothelial, and syncytiotrophoblast cells [237–239], which are implicated in the pathophysiology of preeclampsia [240–243]. The gene discussed is CD44; the disease is preeclampsia.