At 22.1–28 weeks of gestation, the proteins most often selected in the best risk model for early preeclampsia out of 200 bootstrap iterations were sialic acid binding immunoglobulin-like lectin 6 (siglec-6) (58%), PlGF (52%), activin-A (25%), and VEGF121 (18%). Here, PGF is linked to preeclampsia.