The c.35delG has been detected as the most frequent GJB2 pathogenic mutation in Mediterranean, North American and European patients with NSHL (Petersen & Willems, 2006; Stenson et al., 2009) This mutation creates a premature stop codon which is resulted from deletion of a guanine residue within a stretch of Gs between nucleotide positions 30 and 35 (Denoyelle et al., 1997). The gene discussed is GJB2; the disease is nodular sclerosis classical Hodgkin lymphoma.