Previously, we reported that activation of the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway by cholera toxin can induce malignant glioma cell differentiation into benign astrocyte‐like cells, which are characterized by proliferation arrest and glial fibrillary acidic protein (GFAP) expression (Li al., 2007). The gene discussed is GFAP; the disease is malignant glioma.