The second most common subtype (MetB) shows poor prognosis after ADT and some features similar to neuroendocrine tumors, such as high cell cycle activity and DNA damage (Flores‐Morales et al., 2019), but as chromogranin expression is generally low and KRT18 and AR expression retained, we suggest that MetB shows a dedifferentiated luminal phenotype. Here, KRT18 is linked to neuroendocrine neoplasm.