The contrasting processes of cell differentiation and proliferation are both driven by androgens in the prostate (Cai et al., 2011; Gao et al., 2016; Yang et al., 2016), but in a context‐dependent way that seems reprogrammed during cancer progression by coactivators and corepressors modulating the AR cistrome (Sharma et al., 2013; Liu et al., 2017). The gene discussed is AR; the disease is cancer.