HIF‐1α is a critical regulator of metastatic niche formation in the development of breast cancer (BrCa) probably through induction of LOXL2.26 Retarding HIF‐1α (knockdown/deficiency), or reducing hypoxia‐induced LOX family members in BrCa suppresses primary tumor growth in parallel with the metastasis of BrCa cells to the lungs. This evidence concerns the gene LOX and invasive breast carcinoma.