Phytochemicals can be used in adjuvant therapies in conventional anticancer treatment.7 Salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea L, possesses antioxidant and antihypoxic properties.8, 9 Currently, antitumor effect of salidroside has been proved in human breast cancer,10 fibrosarcoma,11 skin cancer,12 and renal cell carcinoma.13 Salidroside regulates the expression of HIF‐1α in hypoxia‐injured cardiomyocytes.14 However, whether salidroside plays a role in PC progression and whether HIF‐1α and LOXL2 were involved in this process remained largely unknown. Here, HIF1A is linked to skin neoplasm.