HIF1A and pachyonychia congenita: 26, 27 Moreover, a PC in vivo experiment suggested that salidroside suppressed tumor growth, increased cell apoptosis, inhibited the metastasis of BxPC‐3 cells to the lung, and reduced HIF‐1α, LOXL2, MMP2, and MMP9 while enhanced E‐cadherin in tumor tissue (Figure 5).