In hypoxia‐injured cardiomyocyte, salidroside is an inducer of HIF‐1α expression, and favors HIF‐1α translocation.14 In osteoporosis, salidroside inhibits HIF‐1α expression and translocation, however, increases the HIF‐1α transcriptional activity.8 Interestingly, our work showed that salidroside inhibited HIF‐1α expression and the transcriptional activity in hypoxia‐injured BxPC‐3 cells (Figure 2C and 2D), suggesting that salidroside may decrease HIF‐1α stability, and thereby influence HIF‐1α levels. Here, HIF1A is linked to osteoporosis.