HDAC2 and breast cancer: HDAC inhibition in the human colorectal carcinoma HCT 116 and breast cancer MDA-MB 231 cell lines also resulted in an overall increase in H3 acetylation, as well as an increase in H3K4me3 along exon 2 of MCL1. In addition, there was a reduction in the association of HDAC1, HDAC2, and SRSF1 with exon 2, but an increase in the acetyltransferase PCAF.