These experiments revealed a similar, though somewhat less severe, inflammatory phenotype associated with the development of ANAs, which was also suppressed by combined inactivation of Phd2 with Hif2a. Though it is possible that this phenotype was obscured in the earlier studies by other, ultimately fatal, consequences of Phd2 inactivation, we note that one of the earlier reports of Phd2-KO mice noted the occurrence of leukocytosis and thrombocytosis, such as we observed in the present study (14). This evidence concerns the gene EPAS1 and Increased total leukocyte count.