TNFRSF8 and anaplastic large cell lymphoma: Chen et al. proposed that drug transporters can play a role in ADCETRIS® drug resistance in Hodgkin’s lymphoma, they found the HL cell line L428, but not the ALCL cell line Karpas 299, exhibited MMAE resistance and increased expression of the MDR1 drug exporter compared with the parental line.18 Although MMAE can be actively pumped out of the cell by P-glycoprotein or other transporters, there are other cytotoxic agents that can be linked to ADCs that are not substrates for transport, and these could be utilized as CD30 immunoconjugates in the future.