AKT1 and myocardial ischemia: Akt activation mechanisms are of significant interest in cardiac tissue as well where stimulation of Akt (indicated by phosphorylation at serine 473; AktpS473) has been implicated in protection following myocardial ischemia [21], mediating the apoptotic response [22], as well as modulating several other physiological events in myocardial tissue [23,24].