INS and type 2 diabetes mellitus: As recommended by the American Diabetes Association guideline5, 6 and the China Diabetes Society guideline7, 8, for newly diagnosed type 2 diabetes patients, oral hypoglycemic agents (OHAs) monotherapy or combination therapy, or in combination with insulin therapy are strategies that can be selected individually according to the patient's glycated hemoglobin A1c (HbA1c) level5, 6.