The reasons for connecting HHV-1 with AD come from data linking HHV-1 directly to the main neuropathological features of AD: amyloid plaques and neurofibrillary tangles (NFT), which comprise mainly of β-amyloid (Aβ) and abnormally phosphorylated tau protein (Santana et al. 2012; Alvarez et al. 2012; Wozniak et al. 2009). This evidence concerns the gene MAPT and Alzheimer disease.