AGT and Shock: Following the pilot study, the randomized, double-blind, phase 3 Angiotensin II for the Treatment of High-Output Shock (ATHOS-3) trial (ClinicalTrials.gov, NCT02338843) demonstrated that angiotensin II significantly increased MAP and provided a catecholamine-sparing effect versus placebo in patients with catecholamine-resistant vasodilatory shock [15].