By including six variables (age at diagnosis, BMI, HbA1c, GAD autoantibodies, C-peptide and glucose [for estimation of insulin secretion, HOMA-B and insulin-sensitivity, HOMA-IS]) in a clustering analysis of individuals with newly diagnosed diabetes, we could break down classical type 2 diabetes into five distinct subgroups, with better prediction of disease progression and outcome [2]. The gene discussed is INS; the disease is diabetes mellitus.