First examples of genome-edited hPSC models to elucidate the role of specific type 2 diabetes-associated SNPs are starting to appear, as exemplified by a report where CRISPR-Cas9-edited hiPSCs and EndoC-βH1 cells were used to investigate the mechanisms of a protective zinc transporter 8 (Znt8, SLC30A8) variant [51]. The gene discussed is SLC30A8; the disease is type 2 diabetes mellitus.