NF1 and NF2 were considered to represent alternate presentations of a single syndrome by Harvey Cushing, and in the decades following the 1917 publication of Tumors of the Nervus Acusticus and the Syndrome of the Cerebellopontine Angle, neurofibromatosis cases were frequently given a unifying diagnosis of von Recklinghausen’s disease [6]. This evidence concerns the gene NF1 and neoplasm.