TNF and neoplasm: Indeed, CT treatment of Hepa1-6-bearing mice resulted in the selective upregulation of an array of genes indicative of DC maturation, activation of TAMs toward M1 type, Th1 polarization, and generation of antitumor immune defense, including CXCL9-11, IFNγ, perforin, granzyme B, iNOS, IFNα, IFNβ, IL-12p40, and TNFα in the tumor tissue (Fig. 6e and sFig. 7).