Measurement of the expression of a panel of genes in Hepa1-6 tumors showed that CT treatment significantly upregulated the expression of CXCL9, CXCL10, CXCL11, IFNγ, perforin, granzyme B, iNOS, IFNα, IFNβ, IL-12p40, and TNFα in the tumor tissue (Fig. 6e and sFig. 7). The gene discussed is PRF1; the disease is neoplasm.