RB1 and prostate cancer: It has been reported that CT induced a G1/G0 cell-cycle arrest in rhabdomyosarcoma (Rh30) and prostate cancer (DU145) cells by downregulating expression of cyclin D1 and phosphorylation of retinoblastoma protein (Rb) [25], but that CT induced a G2/M cell-cycle arrest in lung (A549) cells via upregulating expression of cyclin-dependent kinases (CDK) [6].