TYW1 and leukemia: It would therefore seem to lead to abnormal tyrosine kinase activity in a manner similar to what has been seen for other PDGFRB fusion proteins.<h4>Conclusions</h4>The examined pediatric leukemia is a Ph-like ALL which carries novel <i>GTF2I</i>-<i>PDGFRB</i> and <i>IKZF1</i>-<i>TYW1</i> fusion genes together with additional submicroscopic deletions.