Since ZNF503 has been reported to increase cell viability and the capacity of invasion [17], our results suggest that the NCI-H1650 cell growth and invasion that was inhibited by miR-340-5p should be dependent on ZNF503 and that inhibition of ZNF503 may synergize with miR-340-5p against NSCLC. The gene discussed is ZNF503; the disease is non-small cell lung carcinoma.