Core analyses determined the top 5 canonical pathways associated with upregulated proteins to be: (1) LXR/RXR activation, (2) FXR/RXR activation, (3) acute phase response signaling, (4) atherosclerosis signaling and (5) IL-12 signaling and production in macrophages, several of which have been previously associated with IA. This evidence concerns the gene NR1H4 and atherosclerosis.