However, these TF path-related markers can be explained by alternative mechanisms, including acute DIC with hepatic coagulopathy, combined micro-macrothrombotic syndrome, concomitant vascular injury as a result of surgery and vascular access, and perhaps more commonly MODS resulting in tissue necrosis, especially of the liver, kidneys and lungs, in advancing severe sepsis. The gene discussed is TF; the disease is blood coagulation disease.