Sepsis-associated coagulopathy has shown to express the changes in antithrombotic and prothrombotic markers, which include TF path-related markers such as thrombin, antithrombin, thrombin-antithrombin complexes, activated protein C (APC), tissue factor pathway inhibitor (TFPI), and thrombomodulin (TM). This evidence concerns the gene TFPI and blood coagulation disease.