Strikingly, four genes; MLL1 (p = 0.012), MLL2 (p = 0.024), SMYD2 (p = 0.016) and NSD2 (p = 0.004) was significantly increased in ccRCC in comparison to normal tissues (Fig. 4i–l). This evidence concerns the gene KMT2A and nonpapillary renal cell carcinoma.